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Hyponatraemia (serum sodium concentration below 135 mmol/L) is the most common electrolyte disturbance and occurs commonly in older people. The causes can be complex to diagnose and treat and many published guidelines do not focus on the issues in an older patient group. Here, we are principally concerned with diagnosis and management of euvolaemic and hypervolaemic hyponatraemia in hospitalised patients...
Several BCR‐ABL1 tyrosine kinase inhibitors (TKIs) are approved for the first‐line treatment of chronic phase chronic myeloid leukaemia (CML). Disease control is achieved in the vast majority of patients and disease‐specific survival is excellent. Consequently, there is now emphasis on managing comorbidities and minimising treatment‐related toxicity. Second‐generation TKIs have cardiovascular risks...
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